Evaluation of the neo-glottal closure based on the source description in esophageal voice

The characteristics of esophageal voice render its study by traditional acoustic means to be limited and complicate. These limitations are even stronger when working with patients lacking minimal skills to control the required technique. Nevertheless the speech therapist needs to know the performance and mechanics developed by the patient in producing esophageal voice, as the specific techniques required in this case are not as universal and well-known as the ones for normal voicing. Each patient develops different strategies for producing esophageal voice due to the anatomical changes affecting the crico-pharyngeal sphincter (CPS) and the functional losses resulting from surgery. Therefore it is of fundamental relevance that practitioners could count on new instruments to evaluate esophageal voice quality, which on its turn could help in the enhancement of the CPS dynamics. The present work carries out a description of the voice of four patients after undergoing laryngectomy on data obtained from the study of the neo-glottal wave profile. Results obtained after analyzing the open-close phases and the tension of the muscular body on the CPS are shown

An application of multiobjetive programming to the study of workers' satisfaction in the spanish labour market

In this paper, a multiobjective scheme is used to study the satisfaction levels of the Spanish workers. Data obtained from a panel survey conducted in several European countries are used to build up a multiobjective model, on the basis of a previous statistical and econometric analysis of these data. Then, a Reference Point based method is implemented to determine the profile of the most satisfied worker in Spain nowadays. Finally, a combined Goal Programming – Reference Point approach is used to determine policies than can be carried out in order to increase the workers’ satisfaction levels.Workers’ Satisfaction, Econometric analyses, Multiobjective Programming.

Discrete sub- and supersolutions method

Mención Internacional en el título de doctorThis thesis develops the discrete sub- and supersolutions method and applies it to prove the convergence of the nonlinear finite element method applied to the generalized di usive logistic equation......Este trabajo ha sido desarrollado en el Departamento de Matemáticas de la Universidad Carlos III de Madrid (UC3M) bajo la dirección de la profesora Marcela Molina Meyer. Se contó con una beca de la UC3M de ayuda al estudio de máster de dos años de duración y posteriormente con un contrato de investigador en formación de la UC3M durante tres años más. Adicionalmente se recibió una ayuda de la UC3M para realizar una estancia de investigación, financiada por el programa "Ayudas para la movilidad de investigadores de la Universidad Carlos III de Madrid en centros de investigación nacionales o extranjeros, Convocatoria 2015. Modalidad B: investigadores en formación predoctoral". La estancia de investigación se realizó en el Departamento de Matematicas de Heriot-Watt University (Edimburgo). Además, esta tesis ha sido respaldada parcialmente por el Ministerio de Economía y Competitividad de España con el proyecto MTM2015-65899-P y por el Ministerio de Ciencia, Innovación y Universidades de España con el proyecto PGC2018-097104-B-100.Programa de Doctorado en Ingeniería Matemática por la Universidad Carlos III de MadridPresidente: John Werner Peter Volker.- Secretario: Julia María Novo Martín.- Vocal: Sara Polloc

What do teachers think about their profession?

Dado que la actuación de los docentes tiene mucho que ver con sus creencias sobre la naturaleza de la enseñanza y de la educación (Harris, 2011) es importante identificar dichas creencias en la formación del profesorado. Esta investigación tiene como objetivo conocer la opinión que tiene sobre la enseñanza el profesorado en activo. En el estudio han participado 17 profesores de Educación Infantil y Primaria, participantes en actividades de formación continua organizadas y desarrolladas por la Universidad de Deusto. El análisis de contenido de las respuestas a la entrevista estructurada arroja información relevante, con implicaciones interesantes para la formación del profesorado

Imagen del profesor en el grado en educación primaria

La construcción de la identidad profesional es una de las metas educativas de la formación del maestro/a. Esta investigación tiene como objetivo analizar el cambio de la imagen profesional del estudiante del Grado en Educación Primaria durante sus estudios. Han participado en la investigación 134 estudiantes de último curso del Grado en Educación Primaria respondiendo a un cuestionario de preguntas abiertas. Las respuestas de los participantes indican que los estudios del grado han contribuido a cambiar su imagen del profesor ya que les ha ayudado a reconocer la importancia de la figura del profesor, así como a ser conscientes de la complejidad en el desempeño, tanto por la dificultad como por la cantidad de funciones y tareas. Han identificado elementos del perfil profesional, incluyendo algunas de las competencias que favorecen su desempeño. Asimismo, algunos estudiantes declaran haber avanzado en su identificación con la profesión. Estos resultados tienen implicaciones para la formación del profesoradoThe construction of the professional identity is one of the educational goals of teacher training. The target of this investigation is to know how the professional image of teacher has changed during university studies. In the research, 134 students of the last year of the Grade in Primary Education have been involved responding to an open-ended questionnaire. The replies of the participants suggest that the taken studies of the grade have promote to change their image of the teacher as it has helped to recognize the importance of the teacher and also to be aware of the difficulty and complexity of the performance, as well as the number of functions and tasks. They have identified components of the professional profile, including some of the competences that enable their performance. Additionally, some students report to have made progress in their identification with the profession. These results have implications for teacher trainin

Teacher’s professional image in in-service training

La importancia del profesor como educador y formador de ciudadanos proactivos, competentes, flexibles y comprometidos es innegable. Por ello, es importante que los profesores sean competentes para cumplir adecuadamente con sus funciones. Las creencias del profesor sobre la profesión docente, la enseñanza, la organización de clase, etc. influyen en su actuación docente. En consecuencia, es importante identificar dichas creencias como elemento de partida en la formación del profesorado. Esta investigación tiene como objetivo conocer la imagen del profesor y la percepción de la enseñanza del profesorado en activo. Con este fin se ha encuestado a 17 profesores de Educación Infantil y Primaria en ejercicio, participantes en distintas actividades de formación continua organizadas y desarrolladas por la Universidad de Deusto durante el segundo semestre del curso 2012-2013. Los profesores, a través de un cuestionario on line de preguntas abiertas, han explicado, su concepción de la profesión docente, han identificado las características de un buen profesor y las dificultades encontradas durante el desempeño profesional. El análisis de contenido de las respuestas arroja información relevante, con implicaciones interesantes para la formación del profesorado. Los resultados indican que los participantes son conscientes del perfil profesional en cuanto a funciones y competencias e identifican aspectos que dificultan y favorecen su desempeño. La experiencia profesional favorece una imagen más realista de la profesión.The significance of a teacher as an educator and trainer of proactive, capable, flexible and committed citizens is undeniable. Thus, it is important that teachers be proficient to adequately fulfill their duties. Teachers' beliefs about the teaching profession, training, class organization, etc. influence in their teaching behaviour. Therefore, it is important to identify these beliefs as a key element in the teachers´ training. The aim of this research is to determine the image of the teacher and the teaching perception in active teachers. The study involved a group of 17 Pre-primary and Primary Education teachers, engaged in several training activities organized and carried out by the University of Deusto, during the second semester of the 2012-2013 academic years. Teachers, through an online questionnaire with open questions, have explained, among other things, their conception of teaching profession, the characteristics of being a good teacher as well as the difficulties they found during the professional performance. The content analyses of the answers disclose relevant information, with interesting implications for teacher training. Outcomes indicate that participants are aware of the professional profile in terms of roles and competences and identify issues that complicate and promote their teaching. Work experience encourages a more realistic image of the profession

Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells

Sorafenib is the unique accepted molecular targeted drug for the treatment of patients in advanced stage of hepatocellular carcinoma. The current study evaluated cell signaling regulation of endoplasmic reticulum (ER) stress, c-Jun-N-terminal kinase (JNK), Akt, and 5′AMP-activated protein kinase (AMPK) leading to autophagy and apoptosis induced by sorafenib. Sorafenib induced early (3–12 hr) ER stress characterized by an increase of Ser51P-eIF2α/eIF2α, C/EBP homologous protein (CHOP), IRE1α, and sXBP1, but a decrease of activating transcription factor 6 expression, overall temporally associated with the increase of Thr183,Tyr185P-JNK1/2/JNK1/2, Thr172P-AMPKα, Ser413P-Foxo3a, Thr308P-AKt/AKt and Thr32P-Foxo3a/Foxo3a ratios, and reduction of Ser2481P-mammalian target of rapamycin (mTOR)/mTOR and protein translation. This pattern was related to a transient increase of tBid, Bim EL, Beclin-1, Bcl-xL, Bcl-2, autophagy markers, and reduction of myeloid cell leukemia-1 (Mcl-1) expression. The progressive increase of CHOP expression, and reduction of Thr308P-AKt/AKt and Ser473P-AKt/AKt ratios were associated with the reduction of autophagic flux and an additional upregulation of Bim EL expression and caspase-3 activity (24 hr). Small interfering-RNA (si-RNA) assays showed that Bim, but not Bak and Bax, was involved in the induction of caspase-3 in sorafenib-treated HepG2 cells. Sorafenib increased autophagic and apoptotic markers in tumor-derived xenograft model. In conclusion, the early sorafenib-induced ER stress and regulation of JNK and AMPK-dependent signaling were related to the induction of survival autophagic process. The sustained drug treatment induced a progressive increase of ER stress and PERK-CHOP-dependent rise of Bim EL, which was associated with the shift from autophagy to apoptosis. The kinetic of Bim EL expression profile might also be related to the tight balance between AKt- and AMPK-related signaling leading to Foxo3a-dependent BIM EL upregulation.Ministerio de Economía y Competitividad BFU2016‐75352‐PInstituto de Salud Carlos III PI15/00034, PI13/ 00021, PI16/00090, PI14/01349Ministerio de Educación FPU16/05127, FPU12/01433, FPU13/01237Junta de Andalucía CTS-6264, PI-00025-2013, PI-0127-2013, PI-0198-201

Evolución cuaternaria del drenaje en un corredor intramontano: La Canal de Navarrés (Valencia, Spain)

[Resumen] Este artículo analiza la evolución actual y del Cuaternario reciente de la red de drenaje en una fosa intramontana del macizo del Caroig (Valencia). De la información bibliográfica, el análisis geomorfológico y el registro sedimentario obtenido por sondeo mecánico, acompañado de dataciones absolutas C14 y TL, se concluye que claros signos de precariedad en la organización de la red han perdurado, si bien a menor escala, hasta la actualidad[Abstract] This paper is about the drainage network evolution during the Holocene and Late Quaternary in the rift valley of the Caroig massif (Valencia). Geological and geomorphological studies showed halocinesis movements in this graben. Sorne other processes, for instance, aIluvial and coIluvial deposition, moreover lithochemical and biochemical sedimention occured at the same time. The core sediment analysis and C14 and TL datations, allow us to conclude that in this zone, the disruption of the quaternary drainage network persists at the present time, eventhough it is less evident.Dirección General de Investigación Científica y Técnica; PB91-089

Using metaphors to know the conceptions about the teaching profession in initial teacher education

Conceptions about teaching are important because they affect professional performance. Metaphors are a tool to identify them. In this qualitative study metaphors are used to gain insight into conceptions held by pre-service teachers, and their development during Initial Teacher Training in the Bachelor’s Degree in Primary Education.A total of 247 students participated in this cross-sectional study; 145 were first-year students, and 102 were fourth-year students. Participants were requested to submit a metaphor following the open-ended formula: “the teacher is like…. because…” In order to categorize their answers, we used an inductive method. Afterwards, we calculated frequencies and percentages.Metaphors are grouped according to the following categories: a) Main Character; b) Support; c) Family; d) Teaching; e) Importance. The most frequent category is Support, followed by Teaching and Family. First-year pre-service teachers refer to Family, Teaching and the Main Character role of teachers more often than students in their fourth year, whereas the latter allude more often than the former to the teachers’ role as providers of Support and as Social Agents.There is evidence of a development from a transmissive educational perspective to a constructivist and transformative perspective of education, but there is no indication of any evolution towards a socioconstructivist outlook